While Taking This Drug, Observe the Following. Possible Effects of Long-Term Use

Possible Effects of Long-Term Use

Advisability of Use if Breast-Feeding

Presence of this drug in breast milk: Yes.

Avoid drug or refrain from nursing.

Habit-Forming Potential: Use of this drug in large doses for a prolonged period of time may cause a form of psychological dependence.

Effects of Overdosage: Stomach distress, nausea, vomiting, ringing in the ears, dizziness, impaired hearing, sweating, stupor, fever, deep and rapid breathing, muscular twitching, delirium, hallucinations, convulsions.

A form of psychological dependence.

Anemia due to chronic blood loss from erosion of stomach lining.

The development of stomach ulcer.

The development of "aspirin allergy"—nasal discharge, nasal polyps,

asthma.

Kidney damage. Excessive prolongation of bleeding time, of major importance in the event of injury or surgery.

Suggested Periodic Examinations While Taking This Drug (at physician's

discretion)

Complete blood cell counts. Kidney function tests and urine analyses. Liver function tests.

Foods: No restrictions.

Nutritional Support: If supplementing the diet with vitamin C, take no more

than the recommended daily allowance. Do not take large doses of

vitamin С while taking aspirin on a regular basis.

Beverages: No restrictions. May be taken with milk. Alcohol: No interactions expected. However, the concurrent use of alcohol and aspirin may significantly increase the possibility of erosion and ulceration of the stomach lining and may result in bleeding.

Tobacco Smoking: No interactions expected.

Other Drugs

Aspirin may increase the effects of

oral anticoagulants, and cause abnormal bleeding.

Dosage adjustment is often necessary.

oral antidiabetic drugs and insulin, and cause hypoglycemia (see Glossary). Dosage adjustment is often necessary.

heparin, and cause abnormal bleeding.

methotrexate, and increase its toxic effects.

valproic acid (Depakene).
Aspirin may decrease the effects of

· beta-adrenergic-blocking drugs (see Drug Class, Section Four).

· captopril (Capoten).

· probenecid (Benemid), and reduce its effectiveness in the treatment of
gout—with aspirin doses of less than 2 grams/24 hours.

· spironolactone (Aldactone), and reduce its diuretic effect.

· sulfinpyrazone (Anturane), and reduce its effectiveness in the treatment of gout—with aspirin doses of less than 2 grams/24 hours.

· The following drugs may increase the effects of aspirin

· acetazolamide (Diamox).

· para-aminobenzoic acid (Pabalate).

· vitamin C, taken as ascorbic acid and in large doses, may acidify the
urine in some individuals and cause aspirin accumulation and toxicity.

· The following drugs may decrease the effects of aspirin

· antacids, in regular continual use.

· Cortisone like drugs.

· urinary alkalizers (sodium bicarbonate, sodium citrate).

Driving, Hazardous Activities: No restrictions or precautions.

Aviation Note: Usually no restrictions. However, it is advisable to observe

for the possible occurrence of mild drowsiness and to restrict activities

accordingly.

Exposure to Sun: No restrictions.

Discontinuation: The use of aspirin should be discontinued completely at least 1 week before surgery of any kind.

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