Advisability of Use During Pregnancy. Possible Effects on Laboratory Tests

Precautions for Use

CAUTION

Possible Effects on Laboratory Tests

Natural Diseases or Disorders That May Be Activated by This Drug

Adverse Effects That May Mimic Natural Diseases or Disorders

Possible Effects on Sexual Function

Swelling and tenderness of breasts, milk production. Increased vaginal secretions.

Possible Delayed Adverse Effects: Estrogens taken during pregnancy can predispose the female child to the later development of cancer of the vagina or cervix following puberty.

Liver reactions may suggest viral hepatitis.

Latent hypertension, diabetes mellitus, acute intermittent porphyria.

Red blood cells, hemoglobin and platelets: decreased.

Blood calcium level: increased.

Blood total cholesterol level: decreased (treatment effect); increased in

post-menopausal women.

Blood LDL cholesterol level: decreased in post-menopausal women. Blood triglyceride level: no drug effect in postmenopausal women. Blood glucose level: increased. Glucose tolerance test (GTT): decreased. Blood thyroid hormone (T³ and T⁴) levels: increased. Blood uric acid level: decreased. Liver function tests: increased liver enzymes (ALT/GPT, AST/GOT and

alkaline phosphatase), increased bilirubin.

1. To avoid prolonged (uninterrupted) stimulation of breast and uterine tissues, estrogen should be taken in cycles of 3 weeks on and 1 week off of medication.

2. The estrogen in estrogen vaginal creams is absorbed systemically by the woman. It may also be absorbed through the penis during sexual intercourse and can cause enlargement and tenderness of male breast tissue.

By Those over 60 Years of Age: This drug has very limited usefulness after 60. Its use should be restricted to those women who are at increased risk for developing osteoporosis. In this age group, it is advisable to attempt relief of hot flushes with nonestrogenic medications. During use, report promptly any indications of impaired circulation: speech disturbances, altered vision, sudden hearing loss, vertigo, sudden weakness or paralysis, angina, leg pains.

Pregnancy Category: X. See Pregnancy Code inside back cover.

Animal studies: Genital defects reported in mice and guinea pigs; cleft palate reported in rodents.

Human studies: Information from studies of pregnant women indicates that estrogens can masculinize the female fetus. In addition, limb defects and heart malformations have been reported.

It is now known that estrogens taken during pregnancy can predispose the female child to the development of cancer of the vagina or cervix following puberty. Avoid estrogens completely during entire pregnancy.

Дата добавления: 2015-06-25