Example 3. Play is a cherished part of childhood that offers children important developmental benefits and parents the opportunity to fully engage with their children

Example 2

Conclusions

Play is a cherished part of childhood that offers children important developmental benefits and parents the opportunity to fully engage with their children. However, multiple forces are interacting to effectively reduce many children’s ability to reap the benefits of play. As we strive to create the optimal developmental milieu for children, it remains imperative that play is included along with academic and social enrichment opportunities and that safe environments are made available to all children. Further research is needed to explore the appropriate balance of play, academic enrichment, and organized activities for children with different temperaments and social, emotional, intellectual, and environmental needs.

(Source: Kenneth R. Ginsburg. The Importance of Play in Promoting Healthy Child Development and Maintaining Strong Parent-Child Bonds. American Academy of Pediatrics Report, October 9, 2006).

Conclusions

This paper presented the analysis and validation of an in silico virtual patient and model-based virtual trials methodology. The validation approach, as presented, is readily generalized. It takes advantage of a set of independent clinical data comprised of two clinically matched cohorts treated with two different TGC protocols with two different glycemic targets. Three main conclusions can be drawn:

• Self validation indicated a clinically insignificant error in these virtual patient methods due to model and/or clinical compliance. They also showed the impact of some non-compliance independent of model error.

• Cross validation clearly showed that the virtual patient methods and models enabled by patient-specific S_I(t) profiles are effective and the assumption that the S_I(t) profiles are independent of the clinical inputs used to generate them holds.

• Thus, the virtual patients and in silico virtual trial methods presented are validated in their ability to accurately simulate, in advance, the clinical results of an independent TGC protocol, directly enabling rapid design and optimisation of safe and effective TGC protocols with high confidence of clinical success.

Overall, this study further shows the potential and capability of model-based, data driven in silico methods to aid protocol design, as well as the potential for models to provide accurate, safe and effective real-time TGC.

(Source: Chase J.G. et al. Validation of a model-based virtual trials method for tight glycemic control in intensive care. BioMedical Engineering OnLine 2010, 9: 84, http://www.biomedical-engineering-online.com)

Дата добавления: 2014-10-31