One of the pathways is realized through protein tyrosine kinase activity, Ras and the MAPK cascade, leading to expression of the protooncogenes c-Fos, c-Jun, and Elk1
IL-2 signaling is mediated by a multi-chain receptor complex consisting of an alpha (CD25), beta (CD122), and gamma (CD132) chain. The IL-2R alpha subunit primarily increases the affinity of ligand binding and is not known to contain a signaling domain, whereas the beta and gamma subunits participate in both ligand binding and signal transduction. The IL-2R signaling system proceeds through at least three different pathways, which mediate the flow of mitogenic and survival-promoting signals.
IL-2 (Interleukin-2) is a T-Cell-derived cytokine important in the regulation of growth and differentiation of T-Cells, B-Cells, natural killer cells, glioma cells. IL-2 is a 133-aa polypeptide.
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