Интерлейкин-6

IL-2 вовлечен в формирование иммунного ответа. Рекомбинантный IL-2 (aldesleukin, Proleukin) используется для лечения рака и продолжает изучаться как иммуномодулирующий препарат для лечения саркомы Капоши и ВИЧ-инфекции.

The second pathway includes PI-3-R cascade. Akt can also cause stimulation of NF-KappaB activity by up-regulating I-KappaB degradation via phosphorylation of IKKs (I-KappaB Kinases) and by affecting NF-KappaB itself, thereby allowing the transcription of genes involved in promoting survival, such as BCL. The transcription factors activated by PI3K and PKB are of great interest in IL-2 response, as they regulate the genes responsible for determining whether activated T-Cells survive, proliferate, or die.

Phosphorylation of the cytoplasmic domains of the beta- and gamma-subunits of the IL-2R provides docking sites for the JAK1/3, which, after autophosphorylation, phosphorylates STAT3 and STAT5. Phosphorylation induces dimerization and nuclear translocation of STAT3 and STAT5 complexes, where they promote specific target gene transcription.

IL-6 is a cytokine that provokes a broad range of cellular and physiological responses, including the immune response, inflammation, hematopoiesis, and oncogenesis by regulating cell growth, gene activation, proliferation, survival, and differentiation. IL-6 acts via a receptor composed of two different subunits, an alpha subunit that produces ligand specificity and GP (Glycoprotein) 130, a receptor subunit shared in common with other cytokines in the IL-6 family. Binding of IL-6 to its receptor initiates activation of JAK and activation of Ras-mediated signaling. Activated JAK kinases phosphorylate and activate STAT transcription factors, particularly STAT3 and SHP2 [SH2 Domain-containing Tyrosine Phosphatase].

Дата добавления: 2014-01-14