Mechanism of class II nuclear receptor action

This figure depicts the mechanism of a class I NRs that, in the absence of ligand, is located in the cytosol. Hormone binding to the NR triggers dissociation of heat shock proteins, dimerization, and translocation to the nucleus, where the NR binds to a specific sequence of DNA known as a hormone response element. The nuclear receptor DNA complex in turn recruits other proteins that are responsible for transcription of downstream DNA into mRNA, which is eventually translated into protein, which results in a change in cell function.

Mechanism of class I nuclear receptor action.

Type IV nuclear receptors bind either as monomers or dimers, but only a single DNA binding domain of the receptor binds to a single half site HRE. Examples of type IV receptors are found in most of the NR subfamilies.

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