Once activated by estrogen, the estrogen receptor is able to bind to DNA and regulate the activity of many different genes

A dimer of the ligand-binding region of ERα

There are two different forms of the estrogen receptor, usually referred to as α and β, each encoded by a separate gene (ESR1 and ESR2, respectively). Hormone-activated estrogen receptors form dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα (αα) or ERβ (ββ) homodimers or ERαβ (αβ) heterodimers.

The domain structures of ERα and ERβ, including some of the known phosphorylation sites involved in ligand-independent regulation.

Дата добавления: 2014-01-14