Betaxolol taken concurrently with

While Taking This Drug, Observe the Following

Advisability of Use if Breast-Feeding

Advisability of Use During Pregnancy

Pregnancy Category: C (tentative). See Pregnancy Code inside back cover.

Animal studies: Rat studies reveal increased resorptions of embryo and fetus, retarded growth and development of newborn and mild skeletal defects.

Human studies: Information from adequate studies of pregnant women is not available.

Avoid use of drug during the first 3 months if possible. Avoid use during labor and delivery because of the possible effects on the newborn infant.

Presence of this drug in breast milk: Yes.

Avoid drug if possible. If drug is necessary, observe nursing infant for slow heart rate and indications of low blood sugar.

Habit-Forming Potential: None.

Effects of Overdosage: Weakness, slow pulse, low blood pressure, fainting, cold and sweaty skin, congestive heart failure, possible coma and con­vulsions.

Possible Effects of Long-Term Use: Reduced heart reserve and eventual heart failure in susceptible individuals with advanced heart disease.

Suggested Periodic Examinations While Taking This Drug (at physician's

discretion) Measurements of blood pressure, evaluation of heart function.

Foods: No restrictions. Avoid excessive salt intake.

Beverages: No restrictions. May be taken with milk.

Alcohol: Use with caution until the combined effect has been determined.

Alcohol may exaggerate this drug's ability to lower blood pressure and

may increase its mild sedative effect. Tobacco Smoking: Nicotine may reduce this drug's effectiveness in treating

high blood pressure. In addition, high doses of this drug may potentiate

the constriction of the bronchial tubes caused by regular smoking. Other Drugs Betaxolol may increase the effects of

• other antihypertensive drugs and cause excessive lowering of blood
pressure. Dosage adjustments may be necessary.

• reserpine (Ser-Ap-Es, etc.) and cause sedation, depression, slowing of
heart rate and lowering of blood pressure (light-headedness, fainting).

• clonidine (Catapres) requires close monitoring for rebound high blood
pressure if clonidine is withdrawn while betaxolol is still being taken.

• insulin requires close monitoring to avoid undetected hypoglycemia.

The following drugs may decrease the effects of betaxolol:

indomethacin (Indocin), and possibly other "aspirin substitutes," may impair betaxolol's antihypertensive effect.

Driving, Hazardous Activities: Use caution until the full extent of drowsi­ness, lethargy, and blood pressure change has been determined.

Aviation Note: The use of this drug is a disqualification for piloting. Consult a designated Aviation Medical Examiner.

Exposure to Sun: No restrictions.

Exposure to Heat: Caution advised. Hot environments can lower blood pressure and exaggerate the effects of this drug.

Exposure to Cold: Caution advised. Cold environments can enhance the circulatory deficiency in the extremities that may occur with this drug. The elderly should take precautions to prevent hypothermia (see Glossary).

Heavy Exercise or Exertion: It is advisable to avoid exertion that produces light-headedness, excessive fatigue, or muscle cramping. The use of this drug may intensify the hypertensive response to isometric exercise.

Occurrence of Unrelated Illness: The fever that accompanies systemic infec­tions can lower blood pressure and require adjustment of dosage. Ill­nesses that cause nausea or vomiting may interrupt the regular dosage schedule. Ask your physician for guidance.

Discontinuation: It is advisable to avoid sudden discontinuation of this drug in all situations. If possible, gradual reduction of dose over a period of 2 to 3 weeks is recommended. Ask your physician for specific guidance.

Дата добавления: 2015-06-25