Possible Effects on Laboratory Tests

Adverse Effects That May Mimic Natural Diseases or Disorders

Possible Adverse Effects (unusual, unexpected and infrequent reactions) If any of the following develop, consult your physician promptly for guidance.

This Drug Should Not Be Taken If

· you have had an allergic reaction or unfavorable response to any form of aspirin previously.

·you have any type of bleeding disorder (such as hemophilia).

·you have active peptic ulcer disease.

·you are in the last 3 months of pregnancy.

· it has an odor resembling vinegar. This is due to the presence of acetic
acid and indicates the decomposition of aspirin.

· Inform Your Physician Before Taking This Drug If

· you are taking any anticoagulant drug.

· you are taking oral antidiabetic drugs.

· you have a history of peptic ulcer disease or gout.

· you have lupus erythematosus.

· you are pregnant or planning pregnancy.

· you plan to have surgery of any kind in the near future.

Possible Side-Effects (natural, expected and unavoidable drug actions) Mild drowsiness in sensitive individuals.

Mild Adverse Effects

Allergic Reactions: Skin rash, hives, nasal discharge (resembling hay fever), nasal polyps. Stomach irritation, heartburn, nausea, vomiting, constipation.

Serious Adverse Effects

Allergic Reactions: Acute anaphylactic reaction: asthma, unusual bruising due to allergic destruction of blood platelets. Idiosyncratic Reactions: Hemolytic anemia

Erosion of stomach lining, with silent bleeding.

Activation of peptic ulcer, with or without hemorrhage.

Bone marrow depression: fatigue, weakness, fever, sore throat, abnormal bleeding or bruising.

Hepatitis with jaundice: yellow skin and eyes, dark-colored urine, light-colored stool (very rare).

Kidney damage, if used in large doses or for a prolonged period of time.

Possible Effects on Sexual Function: None reported.

Liver damage may suggest viral hepatitis.

Complete blood cell counts: decreased red cells, hemoglobin, white cells and platelets.

Bleeding time: prolonged.

Prothrombin time: increased by large doses; decreased by small doses.

Blood glucose level: decreased in diabetics.

Blood uric acid level: increased by small doses; decreased by large doses.

Liver function tests: increased liver enzymes (ALT/GPT, AST/GOT, alkaline phosphatase).

Kidney function tests: increased blood creatinine and urea nitrogen levels with long-term use; increased protein and kidney cells in urine.

Thyroid function tests: increased T3 uptake, free T3 and free T4; de­creased TSH, T3, T4, and free thyroxine index (FTI).

Pregnancy tests: large doses of aspirin may cause a false positive urine test (mouse and rabbit tests).

Urine sugar tests: false positive with Clinitest or Benedict's solution.

Fecal occult blood test: positive with large doses of aspirin.

Дата добавления: 2015-06-25