Available Dosage Forms and Strengths. TEXT 4. Read the following text and choose the abstract about using metronidazole by a pregnant woman

Principal Uses

METRONIDAZOLE

TEXT 4. Read the following text and choose the abstract about using metronidazole by a pregnant woman.

While Taking This Drug, Observe the Following

Foods: Consult physician regarding salt intake.

Nutritional Support: Do not take potassium supplements unless directed by

your physician.

Beverages: No restrictions. May be taken with milk.

Alcohol: Use caution until combined effect has been determined. Alcohol

may enhance the blood-pressure-lowering effect of this drug.

Tobacco Smoking: No interactions expected.

Other Drugs

Captopril taken concurrently with

• potassium preparations (K-Lyte, Slow-K, etc.) may cause increased blood levels of potassium with risk of serious heart rhythm disturbances.

• potassium-sparing diuretics: amiloride (Moduretic), spironolactone (Aldactazide), triamterene (Dyazide) may cause increased blood levels of potassium with risk of serious heart rhythm disturbances.

The following drugs may decrease the effects of captopril

• indomethacin (Indocin).

• salicylates (aspirin, etc.).

Driving, Hazardous Activities: Usually no restrictions. Be aware of possible drops in blood

Aviation Note: The use of this drug may be a disqualification for piloting. Consult a designated Aviation Medical Examiner.

Exposure to Sun: Caution advised. This drug can cause photosensitivity.

Exposure to Heat: Caution advised. Avoid excessive perspiring with resultant loss of body water and drop in blood pressure.

Occurrence of Unrelated Illness: Report promptly any disorder that causes nausea, vomiting or diarrhea. Fluid and chemical imbalances must be corrected as soon as possible.

(me troh Ni da zohl)

Introduced: 1960

Prescription: USA: Yes Canada: Yes

Available as Generic: Yes

Class: Anti-infective

Controlled Drug: USA: No Canada: No

Brand Names: Apo-Metronidazole, Flagyl, Metizol, MetroGel, Metryl, Neo-Tric, Novonidazole, PMS-Metronidazole.

As a Single Drug Product: Used primarily to treat trichomonas infections of the vaginal canal and cervix and of the male urethra. It is also used to treat amebic dysentery, giardia infections of the intestine and serious infections caused by certain strains of anaerobic bacteria. A more recent use is the treatment of rosacea with local application of a gel dosage form.

How This Drug Works: By interacting with DNA, this drug destroys essential components of the nucleus that are necessary for the cell life and growth of infecting organisms.

Gel — 0.75%

Injection — 500 mg per 100 ml

Tablets — 250 mg, 500 mg

Usual Adult Dosage Range: Varies with infection to be treated.

For trichomoniasis: One-day course—2 grams as a single dose; or 1 gram for 2 doses 12 hours apart. Seven-day course—250 mg 3 times/day for 7 consecutive days. (The 7-day course is preferred.)

For amebiasis: 500 to 750 mg 3 times/day for 5 to 10 consecutive days.

For giardiasis: 2 grams once/day for 3 days; or 250 to 500 mg 3 times/day for 5 to 7 days.

The total daily dosage should not exceed 4 grams (4000 mg).Note: Actual dosage and administration schedule must be determined by the physician for each patient individually.

Dosing Instructions: May be taken with or following food to reduce stomach irritation. The tablet may be crushed for administration.

Usual Duration of Use: Continual use on a regular schedule as outlined is necessary to ensure this drug's effectiveness. Do not repeat the course of treatment without your physician's approval.

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