Other Drugs Estrogens taken concurrently with

While Taking This Drug, Observe the Following

Advisability of Use if Breast-Feeding

Presence of this drug in breast milk: Yes, in minute amounts.

Estrogens in large doses can suppress milk formation. Breast-feeding is considered to be safe during the use of estrogens.

Habit-Forming Potential: None.

Effects of Overdosage: Headache, drowsiness, nausea, vomiting, fluid retention, abnormal vaginal bleeding, breast enlargement and discomfort.

Possible Effects of Long-Term Use: High blood pressure, gallbladder disease with gallstone formation, increased growth of benign fibroid tumors of the uterus. Several reports suggest possible association between the long-term use (3 + years) of estrogens and the development of cancer of the lining of the uterus. Further studies are needed to establish a definite cause-and-effect relationship. Prudence dictates that women with uterus intact should use estrogens only when symptoms justify it and with proper supervision.

Suggested Periodic Examinations While Taking This Drug (at physician's

discretion)

Regular (every 6 months) evaluation of the breasts and pelvic organs, including Pap smears. Liver function tests as indicated.

Foods: Avoid excessive use of salt if fluid retention occurs.

Beverages: No restrictions. May be taken with milk.

Alcohol: No interactions expected.

Tobacco Smoking: Recent studies indicate that heavy smoking (15 or more cigarettes daily) in association with the use of estrogen-containing oral contraceptives significantly increases the risk of heart attack (coronary thrombosis). Avoid heavy smoking during long-term estrogen therapy.

• antidiabetic drugs may cause unpredictable fluctuations of blood sugar.

• tricyclic antidepressants (Elavil, Sinequan, etc.) may enhance their adverse effects and reduce their antidepressant effectiveness.

• warfarin (Coumadin) may cause unpredictable alterations of prothrombin activity.

The following drugs may decrease the effects of estrogens

• carbamazepine (Tegretol).

• phenobarbital.

• phenytoin (Dilantin).

• primidone (Mysoline).

• rifampin (Rifadin, Rimactane).

Driving, Hazardous Activities: Usually no restrictions. Consult your physician for assessment of individual risk and for guidance regarding specific restrictions.

Aviation Note: Usually no restrictions. However, it is advisable to observe for the rare occurrence of disturbed vision and to restrict activities accordingly. Consult a designated Aviation Medical Examiner.

Exposure to Sun: Use caution until full effect is known. These drugs can cause photosensitivity.

Discontinuation: It is advisable to discontinue estrogens periodically to determine if a need for them still exists. Reduce the dose gradually to prevent acute withdrawal hot flushes. Avoid continual, uninterrupted use of large doses. Discontinue altogether when a definite indication for replacement therapy no longer exists. Ask your physician for guidance.

Дата добавления: 2015-06-25