Inform Your Physician Before Taking This Drug If. This Drug Should Not Be Taken If

This Drug Should Not Be Taken If

Usual Adult Dosage Range:For conjugated and esterified estrogens: 0.3 to 1.25 mg daily for 21 days. Omit for 7 days. Repeat cyclically as needed. For other forms of estrogen: consult your physician. Note: Actual dosage and administration schedule must be determined by the physician for each patient individually.

Available Dosage Forms and Strengths

Capsules — 12 mg, 25 mg, 72 mg (TACE)

Tablets — 0.02 mg, 0.05 mg, 0.1 mg, 0.3 mg, 0.5 mg, 0.625 mg, 0.9 mg, 1.25 mg, 2.5 mg, 5 mg

Transdermal patch — 0.05 mg, 0.1 mg

Vaginal cream — 0.1 mg, 0.625 mg, 1.5 mg per gram

Dosing Instructions: May be taken without regard to food. The tablets may

be crushed for administration. The capsules should be taken whole.

Usual Duration of Use: Continual use on a regular schedule for 10 to 20 days is usually necessary to determine this drug's effectiveness in relieving menopausal symptoms. Long-term use requires supervision and periodic evaluation by your physician every 6 months. Consult your physician on a regular basis.

• you have had a significant allergic reaction to any dosage form of it previously.

• you have a history of thrombophlebitis, embolism, heart attack or stroke.

• you have seriously impaired liver function.

• you have abnormal and unexplained vaginal bleeding.

• you have sickle cell disease.

• you are pregnant.

• you have had an unfavorable reaction to estrogen therapy previously.

• you have a history of cancer of the breast or reproductive organs.

you have any of the following conditions: fibrocystic breast changes, fibroid tumors of the uterus, endometriosis, migrainelike headaches, epilepsy, asthma, heart disease, high blood pressure, gallbladder disease, diabetes or porphyria.

• you smoke tobacco on a regular basis.

• you plan to have surgery in the near future.

Possible Side-Effects (natural, expected and unavoidable drug actions) Fluid retention, weight gain, "breakthrough" bleeding (spotting in middle of menstrual cycle), altered menstrual pattern, resumption of menstrual flow (bleeding from the uterus) after a period of natural cessation (postmenopausal bleeding), increased susceptibility to yeast infection of the genital tissues.

Possible Adverse Effects (unusual, unexpected and infrequent reactions) If any of the following develop, consult your physician promptly for guidance.

Mild Adverse Effects

Allergic Reactions: Skin rash, hives, itching.

Headache, nervous tension, irritability, accentuation of migraine headaches.

Nausea, vomiting, bloating, diarrhea.

Tannish pigmentation of the face. Serious Adverse Effects

Idiosyncratic Reaction: Cutaneous porphyria - fragility and scarring of the skin.

Emotional depression, rise in blood pressure (in susceptible individuals).

Gallbladder disease, benign liver tumors, jaundice, rise in blood sugar.

Erosion of uterine cervix, enlargement of uterine fibroid tumors.

Thrombophlebitis (inflammation of a vein with formation of blood clot) — pain or tenderness in thigh or leg, with or without swelling of foot or leg.

Pulmonary embolism (movement of blood clot to lung) — sudden shortness of breath, pain in chest, coughing, bloody sputum.

Stroke (blood clot in brain)—headaches, blackout, sudden weakness or paralysis of any part of the body, severe dizziness, altered vision, slurred speech, inability to speak.

Retinal thrombosis (blood clot in eye vessels) — sudden impairment or loss of vision.

Heart attack (blood clot in coronary artery) — sudden pain in chest, neck, jaw or arm; weakness; sweating; nausea.

Дата добавления: 2015-06-25