Advisability of Use During Pregnancy. Possible Effects on Laboratory Tests

Precautions for Use

CAUTION

Possible Effects on Laboratory Tests

Natural Diseases or Disorders That May Be Activated by This Drug

Systemic lupus erythematosus.

Complete blood cell counts: decreased red cells, hemoglobin, white cells ■ and platelets; increased eosinophils (allergic reaction). Blood lupus erythematosus (LE) cells: positive. Prothrombin time: increased.

Liver function tests: increased liver enzymes (AST/GOT and alkaline phosphatase).

1. Antacids, dairy products and preparations containing aluminum,
bismuth, calcium, iron, magnesium or zinc can prevent adequate
absorption of this drug and reduce its effectiveness significantly.

2. Troublesome and persistent diarrhea can develop in sensitive individuals. If diarrhea persists for more than 24 hours, discontinue
this drug and consult your physician.

3. If surgery under general anesthesia is required while taking this
drug, the choice of anesthetic agent must be considered carefully to
prevent serious kidney damage.

By Infants and Children: If possible, tetracyclines should not be given to children under 8 years of age because of the risk of permanent discoloration and deformity of the teeth. Rarely, young infants may develop increased intracranial pressure within the first 4 days of receiving this drug. Tetracyclines may inhibit normal bone growth and development.

By Those over 60 Years of Age: Dosage must be carefully individualized and based upon determinations of kidney function. Natural skin changes may predispose to severe and prolonged itching reactions in the genital and anal regions.

Pregnancy Category: D (tentative). See Pregnancy Code inside back cover. Animal studies: Tetracycline causes limb defects in rats, rabbits and

chickens. Human studies: Information from studies of pregnant women indicates that this drug can cause impaired development and discoloration of teeth and other developmental defects. It is advisable to avoid this drug completely during entire pregnancy.

Advisability of Use if Breast-Feeding

Presence of this drug in breast milk: Yes. Avoid drug or refrain from nursing.

Habit-Forming Potential: None.

Effects of Overdosage: Dizziness, nausea, vomiting, diarrhea.

Possible Effects of Long-Term Use: Superinfections; rarely, impairment of bone marrow, liver or kidney function.

Suggested Periodic Examinations While Taking This Drug (at physician's

discretion) Complete blood cell counts, liver and kidney function tests.

During extended use, sputum and stool examinations may detect early superinfection due to yeast organisms.

Дата добавления: 2015-06-25