Available Dosage Forms and Strengths. TEXT 11. Read the following text and put questions to it

Principal Uses

INDOMETHACIN

TEXT 11. Read the following text and put questions to it.

While Taking This Drug, Observe the Following

Foods: No restrictions.

Beverages: No restrictions.

Alcohol: No interactions expected. However, it is best avoided if you have

active liver disease.

Tobacco Smoking: No interactions expected. Other Drugs Tetracyclines may increase the effects of

• oral anticoagulants, and make it necessary to reduce their dosage.

• digoxin (Lanoxin), and cause digitalis toxicity.

• lithium (Eskalith, Lithane, etc.), and increase the risk of lithium toxicity.

Tetracyclines may decrease the effects of

• oral contraceptives, and impair their effectiveness in preventing pregnancy.

• penicillins, and impair their effectiveness in treating infections. Tetracyclines taken concurrently with

• methoxyflurane anesthesia may impair kidney function. The following drugs may decrease the effects of tetracyclines

• antacids (aluminum and magnesium preparations, sodium bicarbonate, etc.) may reduce drug absorption.

• iron and mineral preparations may reduce drug absorption.
Driving, Hazardous Activities: This drug may cause marked dizziness or

incoordination. Restrict activities as necessary. Aviation Note: The use of this drug may be a disqualification for piloting.

Consult a designated Aviation Medical Examiner. Exposure to Sun: Use caution until sensitivity has been determined. Some tetracyclines can cause photosensitivity.

(in doh METH a sin)

Introduced: 1963

Prescription: USA: Yes Canada: Yes

Available as Generic: USA: Yes Canada: No

Class: Mild analgesic, antiinflammatory

Controlled Drug: USA: No Canada: No

Brand Names: Apo-Indomethacin, Indameth, Indocid, Indocid PDA, Indocin, Indocin-SR, Novomethacin

As a Single Drug Product: Used primarily to relieve mild to moderately severe pain associated with (1) musculoskeletal injuries; (2) acute and chronic gout, rheumatoid arthritis and osteoarthritis; (3) dental, obstetrical and orthopedic surgery; (4) menstrual cramps; and (5) vascular (migrainelike) headaches.

How This Drug Works: Not completely established. It is thought that this drug reduces the tissue concentrations of prostaglandins (and related compounds), chemicals involved in the production of inflammation and pain.

Capsules — 25 mg, 50 mg, 75 mg Capsules, prolonged-action — 75 mg

Oral suspension — 25 mg per 5-ml teaspoonful Suppositories — 50 mg

Usual Adult Dosage Range: For arthritis and related conditions: 25 to 50

mg 2 to 4 times daily. If needed and tolerated, dose may be increased by 25 or 50 mg/day at intervals of 1 week. For acute gout: 100 mg initially; then 50 mg 3 times/day until pain is relieved. Total daily dosage should not exceed 200 mg. Note: Actual dosage and administration schedule must be determined by the physician for each patient individually.

Dosing Instructions: Take with or following food to prevent stomach irritation. Take with a full glass of water and remain upright (do not lie down) for 30 minutes. The regular capsule may be opened for adminis­tration, but not the prolonged-action capsule.

Usual Duration of Use: Continual use on a regular schedule for 1 to 2 weeks is usually necessary to determine this drug's effectiveness in relieving the discomfort of arthritis. The usual length of treatment for bursitis or tendinitis is 7 to 14 days. Long-term use requires supervision and periodic evaluation by the physician. Consult your physician on a regular basis.

Дата добавления: 2015-06-25